posted on 2024-03-12, 15:40authored byBehnaz Farajpour, Roujin Heydarzadeh, Faiq H. S. Hussain, Behrouz Notash, Peiman Mirzaei, Morteza Shiri
In this work, a series of novel 3-amino-4H-thieno[3,2-c]coumarins were designed
and synthesized
by a one-pot,
catalyst-free, and three-component reaction of 3-acetylcoumarins with
amines and elemental sulfur. Readily available starting materials,
simple heating conditions, facile installation of a sulfur atom into
the molecule using S8 as a sulfur source, acceptable functional
group tolerance, and synthetically useful yields are some highlighted
benefits of this process.