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Three-Component, One-Pot Sequential Synthesis of N-Aryl, N‘-Alkyl Barbiturates§

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journal contribution
posted on 02.04.2020, 15:42 by Alessandro Volonterio, Matteo Zanda
Condensation between N-alkyl, N‘-aryl carbodiimides and malonic acid monoesters leads to a high-yield formation of N-acyl urea derivatives that could be cyclized to C-monosubstituted barbiturates by addition of a suitable base in a one-pot sequential fashion. In the presence of an electrophile, the last step gives rise to a one-pot, three-component sequential synthesis of fully substituted barbiturates.