np9b00527_si_001.pdf (5.63 MB)
Thiohydantoin and Hydantoin Derivatives from the Roots of Armoracia rusticana and Their Neurotrophic and Anti-neuroinflammatory Activities
journal contribution
posted on 2019-10-18, 14:04 authored by Tae Hyun Lee, Zahra Khan, Sun Yeou Kim, Kang Ro LeeTwo new thiohydantoins (1 and 3) and
three new hydantoins (2, 4, and 5) along with three known compounds (6–8) were isolated from roots of horseradish. Physical data analysis
including NMR (1H and 13C NMR, 1H–1H COSY, HSQC, and HMBC), HRESIMS, and ECD were employed for
structure elucidation of the new compounds 1–5. Potential
neuroprotective effects of all compounds (1–8) on nerve growth factor (NGF) induction in C6 glioma were
also evaluated. Among these compounds, 1b and 2a exhibited potent NGF secretion stimulation activities (NGF secretion
levels: 153.59 ± 5.44% and 141.99 ± 5.21%, respectively).
Their anti-neuroinflammatory activities were also assessed based on
their inhibitory effects on nitric oxide (NO) production in lipopolysaccharide-stimulated
murine microglia. Compound 7 marginally inhibited NO
production with an IC50 value of 32.6 μM.
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NGF secretion stimulation activitiesHydantoin Derivativesnerve growth factorcompoundArmoracia rusticanaPotential neuroprotective effectslipopolysaccharide-stimulated murine microgliaC 6 gliomaanti-neuroinflammatory activitiesHSQCCompound 7structure elucidationCOSYECDHMBCNGF secretion levels1 HAnti-neuroinflammatory Activities1 b32.6 μ M13 C NMRPhysical data analysisnitric oxideIC 50 valueHRESIMS
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