Thiersindoles A−C: New Indole Diterpenoids from Penicillium thiersii
journal contributionposted on 14.08.2003, 00:00 by Chen Li, James B. Gloer, Donald T. Wicklow
Three new 3-substituted indole diterpenoids (thiersindoles A−C; 1−3) have been isolated from organic extracts of a new Penicillium species (P. thiersii). Their structures, including absolute stereochemistry, were determined by analysis of NMR data and application of Mosher's method. Thiersindoles A−C are biogenetically related to the aflavinines, although the [6,6,5] tricyclic diterpenoid skeleton in compounds 1 and 2 is unprecedented in any of the known members of this class.