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Download fileThermodynamic Solubility and Mixing Properties of Phenformin in 14 Pure Solvents at Temperatures Ranging from 278.15 to 323.15 K
journal contribution
posted on 2019-11-12, 17:46 authored by Xi Zhao, Gui Han, Hongkun ZhaoThe equilibrium solubility
of phenformin in 14 solvents of N,N-dimethylformamide (DMF), N-methyl-2-pyrrolidinone
(NMP), dimethyl sulfoxide (DMSO), methanol,
isopropanol, ethanol, n-propanol, 1,4-dioxane, n-butanol, isobutanol, acetonitrile, ethyl acetate, ethylene
glycol (EG), and water was gained using the saturation shake-flask
method over a temperature range of 278.15 to 323.15 K under pressure p = 101.2 kPa. The mole fraction solubility of phenformin
in the above neat solvents increased as the temperature increased
and had a variation trend in the different solvents: DMF > DMSO
>
NMP > EG > methanol > ethanol > ethyl acetate > n-propanol > isopropanol > n-butanol
> isobutanol
> water > acetonitrile > 1,4-dioxane. It was correlated using
the
nonrandom two-liquid model, modified Apelblat equation, λh equation, and the Wilson model. The obtained values of
maximum root-mean-square deviation and relative average deviation
gained via the four models were, respectively, 29.14 × 10–4 and 4.46 × 10–2. Also, the
reduced excess enthalpy, activity coefficient under infinitesimal
concentration, and mixing properties were derived based on the determined
solubility data.