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The Role of the HOOO- Anion in the Ozonation of Alcohols:  Large Differences in the Gas-Phase and in the Solution-Phase Mechanism

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journal contribution
posted on 09.07.2003, 00:00 authored by Anan Wu, Dieter Cremer, Božo Plesničar
The mechanism of the ozonation of isopropyl alcohol was investigated for the gas and the solution phase using second-order many body perturbation theory and density functional theory (DFT) with the hybrid functional B3LYP and a 6-311++G(3df,3pd) basis set. A careful analysis of calculated energies (considering thermochemical corrections, solvation energies, BSSE corrections, the self-interaction error of DFT, etc.) reveals that the gas-phase mechanism of the reaction is dominated by radical or biradical intermediates while the solution-phase mechanism is characterized by hydride transfer and the formation of an intermediate ion pair that includes the HOOO- anion. The product distribution observed for the ozonation in acetone solution can be explained on the basis of the properties of the HOOO- anion. General conclusions for the ozonation of alcohols and the toxicity of ozone (inhaled or administered into the blood) can be drawn.