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The Preparation of a Fully Differentiated “Multiwarhead” Siderophore Precursor

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journal contribution
posted on 23.11.2002, 00:00 by Aaron P. Murray, Marvin J. Miller
A protected, fully differentiated siderophore analogue has been prepared so that “Trojan Horse”-like siderophore drug conjugates with different drugs can be synthesized. The key steps in the synthesis include controlled preparation of an unsymmetrical urea and its conversion to a fully differentiated isocyanurate by reaction with chloro(carbonyl) isocyanate.