np030114z_si_001.pdf (55.25 kB)
The Isolation and Structure Elucidation of Tasiamide B, a 4-Amino-3-hydroxy-5-phenylpentanoic Acid Containing Peptide from the Marine Cyanobacterium Symploca sp.
journal contribution
posted on 2003-07-01, 00:00 authored by Philip G. Williams, Wesley Y. Yoshida, Richard E. Moore, Valerie J. PaulA new cytotoxic peptide, which displayed an IC50 value of 0.8 μM against KB cells, has been isolated
from the marine cyanobacterium Symploca sp. The planar structure of tasiamide B (1), deduced by 2D
NMR experiments, contains the unusual amino acid-derived residue 4-amino-3-hydroxy-5-phenylpentanoic
acid (Ahppa). The configuration of 1 was deduced by HPLC analysis of degradation products.