The Isolation and Structure Elucidation of Tasiamide B, a
4-Amino-3-hydroxy-5-phenylpentanoic Acid Containing Peptide from the Marine
Cyanobacterium Symploca sp.

Williams, Philip G.; Yoshida, Wesley Y.; Moore, Richard E.; Paul, Valerie J.

doi:10.1021/np030114z.s001

np030114z_si_001.pdf (55.25 kB)

The Isolation and Structure Elucidation of Tasiamide B, a 4-Amino-3-hydroxy-5-phenylpentanoic Acid Containing Peptide from the Marine Cyanobacterium Symploca sp.

journal contribution

posted on 2003-07-01, 00:00 authored by Philip G. Williams, Wesley Y. Yoshida, Richard E. Moore, Valerie J. Paul

A new cytotoxic peptide, which displayed an IC₅₀ value of 0.8 μM against KB cells, has been isolated from the marine cyanobacterium Symploca sp. The planar structure of tasiamide B (1), deduced by 2D NMR experiments, contains the unusual amino acid-derived residue 4-amino-3-hydroxy-5-phenylpentanoic acid (Ahppa). The configuration of 1 was deduced by HPLC analysis of degradation products.

The Isolation and Structure Elucidation of Tasiamide B, a 4-Amino-3-hydroxy-5-phenylpentanoic Acid Containing Peptide from the Marine Cyanobacterium Symploca sp.

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