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The First Potent and Selective Non-Imidazole Human Histamine H4 Receptor Antagonists

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journal contribution
posted on 24.07.2003, 00:00 by Jill A. Jablonowski, Cheryl A. Grice, Wenying Chai, Curt A. Dvorak, Jennifer D. Venable, Annette K. Kwok, Kiev S. Ly, Jianmei Wei, Sherry M. Baker, Pragnya J. Desai, Wen Jiang, Sandy J. Wilson, Robin L. Thurmond, Lars Karlsson, James P. Edwards, Timothy W. Lovenberg, Nicholas I. Carruthers
Following the discovery of the human histamine H4 receptor, a high throughput screen of our corporate compound collection identified compound 6 as a potential lead. Investigation of the SAR resulted in the discovery of novel compounds 10e and 10l, which are the first potent and selective histamine H4 receptor antagonists to be described.