The Effect of Varying Substituents on the Equilibrium Distribution and Conformation of Macrocyclic Steroidal <i>N</i>-Acyl Hydrazones

The equilibrium distribution of deoxycholate-based macrocyclic <i>N</i>-acyl hydrazones is dependent upon the nature of the substituents at the 3- and 12-position. These substituents can also influence the preferred conformation of the macrocycles. The conversion of pure cyclic dimer and trimer into a mixture of both components, in the presence of trifluoroacetic acid, has been demonstrated and an X-ray crystal structure obtained of a macrocyclic <i>N</i>-acyl hydrazone dimer.