The Alkaloids of Artabotrys uncinatus
journal contributionposted on 23.08.2001, 00:00 by Tian-Jye Hsieh, Fang-Rong Chang, Yi-Chen Chia, Chung-Yi Chen, Hang-Ching Lin, Huey-Fen Chiu, Yang-Chang Wu
A novel type of α,β-butenolide alkaloid, uncinine (1), two novel oxoaporphines, artabonatine C (2) and artabonatine D (3), a new oxazoloaporphine, artabonatine E (4), and a new 7,7‘-bisdehydroaporphine, artabonatine F (5), along with 25 known alkaloids, were isolated from Artabotrys uncinatus. The structures of 1−5 were determined using NMR and mass spectral data. Atherospermidine and squamolone exhibited cytotoxicity against hepatocarcinoma cancer cell lines (Hep G2 and 2,2,15), and the activity of some of the alkaloids in an antithrombin assay is also discussed.