Multifunctional materials with hemostasis, adhesive,
and antibacterial
properties must be developed to meet the demand for wound hemostasis.
In this work, a hybrid hydrogel (ATD-HAp hydrogel) based on a terpolymer
and hydroxyapatite (HAp) was prepared by photopolymerization within
1 min under green LED irradiation. The polymer chains of ATD-HAp hydrogel
with adjustable tensile and adhesion properties and antibacterial
properties were formed by copolymerization of acrylamide, N-[tris(hydroxymethyl)methyl] acrylamide, and dimethyldiallylammonium
chloride and methacrylated carboxymethyl chitosan as a cross-linking
agent. HAp was added to the hydrogel to release Ca2+ to
promote coagulation. The results showed that ATD-HAp hydrogel had
good tensile (196.7 kPa), wet-adhesive (10.3 kPa), self-healing, antibacterial
properties, and coagulation. And the ATD-HAp hydrogel had excellent
blood compatibility and biocompatibility. Furthermore, the experimental
results of the hemostasis model in mice proved that the ATD-HAp hydrogel
can significantly shorten the hemostasis time and reduce blood loss.
Therefore, the ATD-HAp hydrogel has great potential in the field of
wound hemostasis.