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Terpenoids from <i>Resina Commiphora</i> Regulating Lipid Metabolism via Activating PPARα and CPT1 Expression

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posted on 2020-04-17, 11:33 authored by Si-Si Zhu, Jia-Wang Liu, Yong-Ming Yan, Ying Liu, Zhuo Mao, Yong-Xian Cheng
Commiphoranoids A–E (<b>1</b>–<b>5</b>), five novel sesquiterpenoids, dinorditerpenoids, and heterodimers with unprecedented carbon skeletons, were isolated from <i>Resina Commiphora</i>. The structure of <b>1</b> was secured by X-ray crystallography. Compound <b>4</b> represents the first example of C<sub>38</sub> terpenoids, whereas <b>5</b> is a C<sub>30</sub> terpenoid formed by two types of sesquiterpenoids. These metabolites possess lipid regulatory activities via activating PPARα and CPT1.

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