Terpenoids from Resina Commiphora Regulating Lipid Metabolism via Activating PPARα and CPT1 Expression

Commiphoranoids A–E (1–5), five novel sesquiterpenoids, dinorditerpenoids, and heterodimers with unprecedented carbon skeletons, were isolated from Resina Commiphora. The structure of 1 was secured by X-ray crystallography. Compound 4 represents the first example of C₃₈ terpenoids, whereas 5 is a C₃₀ terpenoid formed by two types of sesquiterpenoids. These metabolites possess lipid regulatory activities via activating PPARα and CPT1.