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Terminal Aziridines by α-Deprotonation/Electrophile Trapping of N-Protected Aziridine

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journal contribution
posted on 21.08.2008, 00:00 by David M. Hodgson, Steven P. Hughes, Amber L. Thompson, Tom D. Heightman
N-tert-Butylsulfonyl and N-tert-butylsulfinyl aziridine undergo α-lithiation/electrophile trapping providing a new entry to terminal aziridines. With N-tert-butylsulfinyl aziridine complete asymmetric induction is observed α to nitrogen.