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Temporal Proteomic Analysis of Intestine Developing Necrotizing Enterocolitis following Enteral Formula Feeding to Preterm Pigs

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journal contribution
posted on 02.01.2009, 00:00 by Pingping Jiang, Per T. Sangild, Wai-Hung Sit, Heidi Hoi-Yee Ngai, Ruojun Xu, Jayda Lee Ann Siggers, Jennifer Man-Fan Wan
Necrotizing enterocolitis (NEC), a serious gastrointestinal inflammatory disease, frequently occurs in preterm neonates that fail to adapt to enteral nutrition. A temporal gel-based proteomics study was performed on porcine intestine with NEC lesions induced by enteral formula feeding. Functional assignment of the differentially expressed proteins revealed that important cellular functions, such as the heat shock response, protein processing; and purine, nitrogen, energy metabolism, were possible involved in the early progression of NEC.