American Chemical Society
ja7b01214_si_001.pdf (4.25 MB)

Templated Self-Assembly of a Covalent Polymer Network for Intracellular Protein Delivery and Traceless Release

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journal contribution
posted on 2017-04-12, 20:49 authored by Kingshuk Dutta, Ding Hu, Bo Zhao, Alexander E. Ribbe, Jiaming Zhuang, S. Thayumanavan
Trafficking proteins inside cells is an emerging field with potential utility in basic cell biology and biological therapeutics. A robust and sustainable delivery strategy demands not only good protection of the cargo but also reversibility in conjugation and activity. We report a protein-templated polymer self-assembly strategy for forming a sheath around the proteins and then tracelessly releasing them in the cytosol. The versatility of the approach, demonstrated here, suggests that the strategy is compatible with a wide array of biologics.