posted on 2013-03-19, 00:00authored byYohei Kotsuchibashi, Roman Vincent C. Agustin, Jin-Yong Lu, Dennis G. Hall, Ravin Narain
Statistical
copolymers of N-isopropylacrylamide
(NIPAAm) and 5-methacrylamido-1,2-benzoxaborole (MAAmBo) have been
synthesized by reversible addition–fragmentation chain transfer
(RAFT) polymerization. The solution properties of the NIPAAm homopolymers
and statistical copolymers were investigated and it was found that,
besides temperature and pH, the statistical copolymers were also responsive
to the presence of free glucose in solution. Furthermore, responsive
hydrogels and nanogels were formed spontaneously by simply mixing
the statistical copolymers of P(NIPAAm-st-MAAmBO)s
and well-defined glycopolymers. These gels were found to have temperature,
pH, and glucose responsive properties.