Telescoped Synthesis of Stereodefined Pyrrolidines
journal contributionposted on 05.07.2013 by Dorine Belmessieri, David B. Cordes, Alexandra M. Z. Slawin, Andrew D. Smith
Any type of content formally published in an academic journal, usually following a peer-review process.
Telescoped and one-pot olefination/asymmetric functionalization approaches to disubstituted pyrrolidines (dr up to 99:1, up to 99% ee) have been developed using commercially available tetramisole (0.1 to 5 mol %). Using OTMS-quinidine as the Lewis base gives preferential access to an anti-configured pyrrolidine in high enantioselectivity.