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Telescoped Synthesis of Stereodefined Pyrrolidines

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journal contribution
posted on 05.07.2013 by Dorine Belmessieri, David B. Cordes, Alexandra M. Z. Slawin, Andrew D. Smith
Telescoped and one-pot olefination/asymmetric functionalization approaches to disubstituted pyrrolidines (dr up to 99:1, up to 99% ee) have been developed using commercially available tetramisole (0.1 to 5 mol %). Using OTMS-quinidine as the Lewis base gives preferential access to an anti-configured pyrrolidine in high enantioselectivity.