Tandem Synthesis of 3‑Halo-5-Substituted Isoxazoles
from 1‑Copper(I) Alkynes and Dihaloformaldoximes

Chen, Wenwen; Wang, Bo; Liu, Nan; Huang, Dayun; Wang, Xinyan; Hu, Yuefei

doi:10.1021/ol503008t.s001

ol503008t_si_001.pdf (6.16 MB)

Tandem Synthesis of 3‑Halo-5-Substituted Isoxazoles from 1‑Copper(I) Alkynes and Dihaloformaldoximes

journal contribution

posted on 2014-12-05, 00:00 authored by Wenwen Chen, Bo Wang, Nan Liu, Dayun Huang, Xinyan Wang, Yuefei Hu

A tandem synthesis of 3-halo-5-substituted isoxazoles has been developed from 1-copper(I) alkynes and dihaloformaldoximes under base-free conditions. Thus, 1,3-dipolar cycloaddition and all its drawbacks can now be avoided completely.

History

Usage metrics

Keywords

cycloaddition drawback dipolar Halo DihaloformaldoximesA tandem synthesis Isoxazole Alkyne dihaloformaldoxime isoxazole alkyne tandem Synthesis

Licence

CC BY-NC 4.0

Exports

RefWorks

BibTeX

Ref. manager

Endnote

DataCite

NLM

DC