Tandem Synthesis of 3‑Halo-5-Substituted Isoxazoles
from 1‑Copper(I) Alkynes and Dihaloformaldoximes

Chen, Wenwen; Wang, Bo; Liu, Nan; Huang, Dayun; Wang, Xinyan; Hu, Yuefei

doi:10.1021/ol503008t.s001

ol503008t_si_001.pdf (6.16 MB)

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Tandem Synthesis of 3‑Halo-5-Substituted Isoxazoles from 1‑Copper(I) Alkynes and Dihaloformaldoximes

journal contribution

posted on 2014-12-05, 00:00 authored by Wenwen Chen, Bo Wang, Nan Liu, Dayun Huang, Xinyan Wang, Yuefei Hu

A tandem synthesis of 3-halo-5-substituted isoxazoles has been developed from 1-copper(I) alkynes and dihaloformaldoximes under base-free conditions. Thus, 1,3-dipolar cycloaddition and all its drawbacks can now be avoided completely.

Tandem Synthesis of 3‑Halo-5-Substituted Isoxazoles from 1‑Copper(I) Alkynes and Dihaloformaldoximes

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