posted on 2011-02-04, 00:00authored byXuesen Fan, Yangyang Wang,, Yingying Qu, Haiyun Xu, Yan He, Xinying Zhang, Jianji Wang
A novel, rapid, and efficient synthesis of bicyclic pyrimidine nucleosides and benzopyran-4-ones through oxidation of homopropargyl alcohols and subsequent isomerization, intramolecular addition of enol to allenic ketone has been developed. This methodology provides an efficient and promising approach to the structurally and pharmaceutically interesting pyrano[2,3-d]pyrimidine-2,5-dione nucleoside and benzopyran-4-one derivatives.