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Tandem Reaction of Tertiary Enamides as a Synthetic Strategy to Construct the Fused N‑Pentacyclic Skeleton of Erythrina Alkaloid Derivatives

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journal contribution
posted on 12.11.2020, 03:13 by Hanlin Yang, Wenzhong Li, Xin-Ming Xu, Zu-Li Wang
An exquisite protocol to the synthesis of erythrina-related structural derivatives was developed, which is composed of a nucleophilic addition of tertiary enamides to ketonic carbonyls and the trapping of acyliminium by an aromatic unit. This protocol afforded a powerful method for the construction of diverse fused N-pentacyclic skeletons in high efficiency and excellent diastereoselectivity by just using different acid catalysts.