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Tandem Processes Identified from Reaction Screening: Nucleophilic Addition to Aryl N-Phosphinylimines Employing La(III)-TFAA Activation

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posted on 2010-05-12, 00:00 authored by Hidenori Kinoshita, Oscar J. Ingham, Winnie W. Ong, Aaron B. Beeler, John A. Porco
Reaction screening of nucleophilic reaction partners for addition to N-diphenylphosphinylimines employing lanthanum(III) triflate as a catalyst and trifluoroacetic anhydride (TFAA) as an activator is reported. A number of tandem processes leading to novel chemotypes including aza-Prins/intramolecular Friedel−Crafts annulations have been identified, and both reaction scope and mechanism further investigated.

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