Tandem Facial Amphiphiles for Membrane Protein Stabilization

Chae, Pil Seok; Gotfryd, Kamil; Pacyna, Jennifer; J. W. Miercke, Larry; G. F. Rasmussen, Søren; Robbins, Rebecca A.; Rana, Rohini R.; Loland, Claus J.; Kobilka, Brian; Stroud, Robert; Byrne, Bernadette; Gether, Ulrik; Gellman, Samuel H.

doi:10.1021/ja1072959.s001

ja1072959_si_001.pdf (738.5 kB)

Tandem Facial Amphiphiles for Membrane Protein Stabilization

journal contribution

posted on 2010-12-01, 00:00 authored by Pil Seok Chae, Kamil Gotfryd, Jennifer Pacyna, Larry J. W. Miercke, Søren G. F. Rasmussen, Rebecca A. Robbins, Rohini R. Rana, Claus J. Loland, Brian Kobilka, Robert Stroud, Bernadette Byrne, Ulrik Gether, Samuel H. Gellman

We describe a new type of synthetic amphiphile that is intended to support biochemical characterization of intrinsic membrane proteins. Members of this new family displayed favorable behavior with four of five membrane proteins tested, and these amphiphiles formed relatively small micelles.