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Tandem Electrophilic Cyclization−[3+2] Cycloaddition−Rearrangement Reactions of 2-Alkynylbenzaldoxime, DMAD, and Br2

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journal contribution
posted on 16.01.2009, 00:00 authored by Qiuping Ding, Zhiyong Wang, Jie Wu
Tandem electrophilic cyclization−[3+2] cycloaddition−rearrangement reactions of 2-alkynylbenzaldoximes, DMAD, and bromine are described, which afford the unexpected isoquinoline-based azomethine ylides in good to excellent yields. The products could be further elaborated via palladium-catalyzed cross-coupling reactions to generate highly functionalized isoquinoline-based stable azomethine ylides.