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Tandem Copper-Catalyzed Conjugate Addition-Diastereoselective Protonation of (E)‑α-Trialkylsilyl-β-Alkyl(Aryl)-α,β-Unsaturated Esters
journal contribution
posted on 2018-09-14, 12:51 authored by David
A. Johnson, Michael P. JenningsA tandem
Cu(I)-catalyzed conjugate addition of Kharasch reagents/diastereoselective
protonation of (E)-α-trialkylsilyl-β-alkyl(aryl)-α,β-unsaturated
esters afforded the saturated products with d.r. values of >20:1
favoring
the anti-diastereomer in modest to excellent isolated yields.