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T-Taxol and the Electron Crystallographic Density in β-Tubulin

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journal contribution
posted on 08.12.2005, 00:00 by Scott A. Johnson, Ana A. Alcaraz, James P. Snyder
T-Taxol has been proposed as the bioactive conformation on β-tubulin and subsequently utilized in the design of a series of highly active bridged taxane analogues. A modified T-form with a reversed C-13 side chain orientation has recently been proposed as an equally plausible bioactive shape. A comparison of the two spatial alternatives within the tubulin binding site electron crystallographic density suggests strongly that T-Taxol is the bioactive conformation.