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TMSOTf-Catalyzed Reactions of N‑Arylynamides with Sulfilimines To Construct 2‑Aminoindoles and α‑Arylated Amidines

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posted on 2024-01-05, 07:30 authored by Xiao-Na Wang, Yanan Wang, Nanfang Wang, Jinyue Chen, Chaofan Qi, Junbiao Chang
Here, we disclose an efficient TMSOTf-catalyzed C–H annulation of aryl-terminated N-arylynamides with sulfilimines, leading to the practical assembly of various valuable 2-aminoindoles in generally moderate to excellent yields with a broad range of functional groups, while nonaryl terminated N-arylynamides undergo TMSOTf-catalyzed aminative arylation with sulfilimines providing α-arylated amidines.

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