American Chemical Society
ol050511w_si_001.pdf (2.81 MB)

Synthetic Studies on the Bryostatins:  Preparation of a Truncated BC-Ring Intermediate by Pyran Annulation

Download (2.81 MB)
journal contribution
posted on 2005-05-26, 00:00 authored by Gary E. Keck, Anh P. Truong
A synthesis of a potential BC-ring subunit (C9−C27) for bryostatin 1, a remarkably potent anticancer agent, has been developed in 16 steps and 18% overall yield. The key features of this route include a BITIP-catalyzed asymmetric allylation reaction, chelation-controlled allylations, a hydroformylation reaction, and a pyran annulation reaction.