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Synthetic Polymer Nanoparticles Conjugated with FimHA from E. coli Pili to Emulate the Bacterial Mode of Epithelial Internalization

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journal contribution
posted on 07.03.2012, 00:00 by Lily Yun Lin, Kristin M. Tiemann, Yali Li, Jerome S. Pinkner, Jennifer N. Walker, Scott J. Hultgren, David A. Hunstad, Karen L. Wooley
Amphiphilic block copolymer nanoparticles are conjugated with uropathogenic Escherichia coli type 1 pilus adhesin FimHA through amidation chemistry to enable bladder epithelial cell binding and internalization of the nanoparticles in vitro.