ja7b01202_si_001.pdf (14.97 MB)
Synthetic Modularity of Protein–Metal–Organic Frameworks
journal contribution
posted on 2017-06-07, 20:18 authored by Jake B. Bailey, Ling Zhang, Jerika A. Chiong, Sunhyung Ahn, F. Akif TezcanPreviously,
we adopted the construction principles of metal–organic
frameworks (MOFs) to design a 3D crystalline protein lattice in which
pseudospherical ferritin nodes decorated on their C3 symmetric vertices with Zn coordination sites were connected
via a ditopic benzene-dihydroxamate linker. In this work, we have
systematically varied both the metal ions presented at the vertices
of the ferritin nodes (Zn(II), Ni(II), and Co(II)) and the synthetic
dihydroxamate linkers, which yielded an expanded library of 15 ferritin–MOFs
with the expected body-centered (cubic or tetragonal) lattice arrangements.
Crystallographic and small-angle X-ray scattering (SAXS) analyses
indicate that lattice symmetries and dimensions of ferritin–MOFs
can be dictated by both the metal and linker components. SAXS measurements
on bulk crystalline samples reveal that some ferritin–MOFs
can adopt multiple lattice conformations, suggesting dynamic behavior.
This work establishes that the self-assembly of ferritin–MOFs
is highly robust and that the synthetic modularity that underlies
the structural diversity of conventional MOFs can also be applied
to the self-assembly of protein-based crystalline materials.
History
Usage metrics
Categories
Keywords
lattice arrangements3 DC 3dihydroxamate linkerslattice conformationslinker componentsditopic benzene-dihydroxamate linkerZn coordination sitesmetal ionsSAXS measurementsconstruction principlespseudospherical ferritin nodeslattice symmetriesprotein latticeSynthetic Modularityferritin nodesMOFsmall-angle X-ray
Licence
Exports
RefWorks
BibTeX
Ref. manager
Endnote
DataCite
NLM
DC