Synthetic Applicability and in Situ Recycling of a B-Methoxy Oxazaborolidine Catalyst Derived from cis-1-Amino-indan-2-ol
journal contributionposted on 05.08.2004, 00:00 by Nathan J. Gilmore, Simon Jones, Mark P. Muldowney
A procedure is described that greatly simplifies the use of an oxazaborolidine catalyst derived from (1R,2S) cis-1-amino-indan-2-ol. This B-OMe catalyst has been employed in the asymmetric reduction of a number of structurally diverse prochiral ketones, in particular the reduction of α-amino acetophenone and its derivatives. A method for reducing the effective catalyst loading by “in situ recycling” is also presented.