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Synthesis of the Tetracyclic Core of Tetrapetalone A Enabled by a Pyrrole Reductive Alkyation

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journal contribution
posted on 15.10.2010, 00:00 by Andrew P. Marcus, Richmond Sarpong
The tetracyclic framework of the tetrapetalone A aglycon has been secured through synthesis. A reductive pyrrole alkylation enables the formation of a key tetrasubstituted carbon stereocenter, and the tetramic acid portion of the molecule can be accessed through silicon or boronic ester conjugate addition to an ene-lactam.