American Chemical Society
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Synthesis of the Repeating Unit of Capsular Polysaccharide Staphylococcus aureus Type 5 To Study Chemical Activation and Conjugation of Native CP5

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journal contribution
posted on 2016-06-15, 00:00 authored by Jagodige P. Yasomanee, Satsawat Visansirikul, Papapida Pornsuriyasak, Melissa Thompson, Stephen A. Kolodziej, Alexei V. Demchenko
The chemical synthesis of the repeating unit of S. aureus capsular polysaccharide type 5 equipped with capping methyl groups at the points of propagation of the polysaccharide sequence is described. This model compound was designed to study activation of the full length polysaccharide for conjugation to a carrier protein.