American Chemical Society
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Synthesis of the Eight Enantiomerically Pure Diastereomers of the 12-F2-Isoprostanes

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journal contribution
posted on 2002-10-11, 00:00 authored by Douglass F. Taber, Ming Xu, John C. Hartnett
Syntheses of the eight enantiomerically pure diastereomers of the 12-F2-isoprostanes (411) are described. The key steps included rhodium-mediated intramolecular cyclopropanation and enzymatic resolution of the racemic diol 12.