Synthesis of the Eight Enantiomerically Pure Diastereomers
of the 12-F2-Isoprostanes

Taber, Douglass F.; Xu, Ming; Hartnett, John C.

doi:10.1021/ja020816v.s002

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Synthesis of the Eight Enantiomerically Pure Diastereomers of the 12-F₂-Isoprostanes

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posted on 2002-10-11, 00:00 authored by Douglass F. Taber, Ming Xu, John C. Hartnett

Syntheses of the eight enantiomerically pure diastereomers of the 12-F₂-isoprostanes (4−11) are described. The key steps included rhodium-mediated intramolecular cyclopropanation and enzymatic resolution of the racemic diol 12.

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Synthesis of the Eight Enantiomerically Pure Diastereomers of the 12-F₂-Isoprostanes

Journal of the American Chemical Society

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cyclopropanation isoprostane intramolecular Enantiomerically Pure Diastereomers racemic diol 12 enantiomerically Synthesi diastereomer Isoprostanes Syntheses

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Synthesis of the Eight Enantiomerically Pure Diastereomers of the 12-F₂-Isoprostanes

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Synthesis of the Eight Enantiomerically Pure Diastereomers of the 12-F2-Isoprostanes

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Synthesis of the Eight Enantiomerically Pure Diastereomers of the 12-F₂-Isoprostanes