posted on 2024-04-03, 12:04authored byShuo Du, Xing Huo, Xiaolei Wang
Cranomycin and jogyamycin, two aminocyclopentitol natural
products,
possess complex structures and potential medicinal properties. This
review describes synthetic studies about the process of making an
advanced intermediate of cranomycin and jogyamycin. This highly functionalized
intermediate, featuring three contiguous amine-substituted stereocenters,
was constructed from cyclopentadiene through a series of reactions
including the nitroso Diels–Alder reaction, nitrogen radical
cyclization reaction, 1,2-nitrogen migration, and stereoselective
nitrogen addition.