Synthesis of the C9−C23 (C9′−C23′) Fragment of the Dimeric Natural Product Rhizopodin

A stereoselective assembly of the C9−C23 (C9′−C23′) fragment of rhizopodin, a 38-membered bis-lactone natural product, has been developed. A highly efficient approach to this fragment assembles >50% of the carbon skeleton and the stereochemical elements present in the natural product.