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Synthesis of the C1−C23 Fragment of Spirastrellolide A

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journal contribution
posted on 19.06.2008, 00:00 by Jin-Haek Yang, Jia Liu, Richard P. Hsung
Synthesis of the C1−C23 fragment in spirastrellolide A is described, featuring a cyclic acetal-tethered RCM for stereoselective constructions of spiroketal, and a 1,3-anti aldol involving methyl ketone enolate and Mukaiyama conditions.