posted on 2021-09-23, 19:38authored byBao-Long Hou, Li-Xuan Li, Chuang-Chuang Li
We herein describe a new approach
for the efficient and asymmetric
construction of the tricyclic core of eurifoloid A, which possesses
a unique and highly strained bicyclo[4.4.1] ring system. A rhodium-catalyzed
intramolecular [3 + 2] dipolar cycloaddition was developed to install
synthetically challenging bridged bicyclo[4.3.1] ring systems. The
reported chemistry shows the feasibility of constructing the eurifoloid
A framework using a diastereoselective intramolecular [3 + 2] cycloaddition
and a ring enlargement.