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Synthesis of the Apoptosis Inducing Agent Apoptolidin. Assembly of the C(16)−C(28) Fragment

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journal contribution
posted on 13.04.2000, 00:00 by Gary A. Sulikowski, Wai-Man Lee, Bohan Jin, Bin Wu
A stereoselective synthesis of the C(16)−C(28) fragment of the apoptosis inducing agent apoptolidin is described. Key steps include two propionate aldol reactions and a stereoselective Mukaiyama aldol addition of enolsilane 19 to β-methoxy aldehyde 4.