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Synthesis of the ABC Ring System of Azaspiracid. 2. A Systematic Study into the Effect of C16 and C17 Substitution on Bis-spirocyclization

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journal contribution
posted on 05.06.2002, 00:00 by Rich G. Carter, David E. Graves, Melissa A. Gronemeyer, Gregory S. Tschumper
A systematic study into the effect of C16 and C17 substitution on the stereochemical outcome of bis-spirocyclization to form the ABC ring system of azaspiracid is disclosed. Successful construction of the natural 10R,13R bis-spirocyclic stereochemistry has been accomplished on the C16 benzyloxy-containing precursor.