ol026033w_si_001.pdf (56.3 kB)

Synthesis of the ABC Ring System of Azaspiracid. 1. Effect of D Ring Truncation on Bis-spirocyclization

Download (56.3 kB)
journal contribution
posted on 05.06.2002, 00:00 by Rich G. Carter, T. Campbell Bourland, David E. Graves
Synthesis of a spirocyclization precursor with a truncated D ring has been accomplished. Subsequent bis-spirocyclization induced the formation of equal amounts of the natural transoidal 10R,13R bis-spirocycle and its cisoidal 10R,13S epimer under an apparent thermodynamically controlled process.

History