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Synthesis of o,p-EDDHA and Its Detection as the Main Impurity in o,o-EDDHA Commercial Iron Chelates

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journal contribution
posted on 20.09.2002, 00:00 by Mar Gómez-Gallego, Miguel A. Sierra, Roberto Alcázar, Pedro Ramírez, Carmen Piñar, María José Mancheño, Sonia García-Marco, Felipe Yunta, Juan José Lucena
Ethylenediamine-N,N‘bis(o-hydroxyphenyl)acetic acid (o,o-EDDHA) is one of the most efficient iron chelates employed to relieve iron chlorosis in plants. However, the presence of positional isomers of EDDHA in commercial iron chelates has been recently demonstrated, and among them, it has been claimed that ethylenediamine-N(o-hydroxyphenylacetic)-N‘(p-hydroxyphenylacetic) acid (o,p-EDDHA) is the main impurity present in EDDHA fertilizers. Here we report the preparation of o,p-EDDHA, a compound whose synthesis had not been previously reported. The synthetic o,p-EDDHA is able to form ferric complexes, and it has been used as a standard in the analysis of the impurities of commercial iron fertilizers. The presence of o,p-EDDHA/Fe3+ in commercial samples has been unambiguously demonstrated by HPLC. Keywords: o,o-EDDHA; o,p-EDDHA; iron chelates; fertilizers

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