Synthesis of (E)/(Z)‑Verbenone Oxime Ethers and Photoresponsive Behavior to Herbicidal Activity

The accumulation of residual active herbicides in the environment can cause a series of problems. It is thus meaningful to explore a photoresponsive herbicide, whose activity can be weakened under the action of light to reduce the negative effect. To this purpose, a series of (E)/(Z)-verbenone oxime ethers were designed, synthesized, and characterized. Oxime ether groups were adopted as the trigger switches. The preliminary screening for herbicidal activity showed that some of them exhibited better or comparable effects than that of the commercial herbicide flumioxazin against Brassica campestris and Echinochloa crusgalli. Meanwhile, five pairs of the target compounds with significantly different herbicidal effects between E- and Z-forms were further investigated for their reversible isomerization reaction and the accompanying variation of herbicidal activity. As a result, the maximum conversion rates were around 50%, and the herbicidal effect of the resulting mixture of E- and Z-isomers decreased outstandingly. The phototransformation mechanism of a pair of isomers (E)-4a and (Z)-4a was preliminarily explored. Besides, a reasonable and effective 3D-quantitative structure–activity relationship model (r² = 0.984 and q² = 0.571) was established and the binding mode was also investigated by molecular docking.