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Synthesis of a Laterally Branched Polyamine from α-Methylene-γ-butyrolactone

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journal contribution
posted on 23.06.2005, 00:00 by Mickaël Jean, Myriam Le Roch, Jacques Renault, Philippe Uriac
A polyamine derivative was prepared from α-methylene-γ-butyrolactone. This method used Michael addition and lactone aminolysis followed by the nucleophilic substitution of the hydroxyl group by an azido group. The coupling of a lipophilic alkyne led to a polyamine that will be probed as a gene transfer agent.