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Synthesis of a Gln-Phe Hydroxy-ethylene Dipeptide Isostere

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journal contribution
posted on 09.12.2004, 00:00 by Bengt Erik Haug, Daniel H. Rich
The protected Gln-Phe hydroxyethylene dipeptide isostere 1 was synthesized as a precursor for preparation of potential inhibitors of Botulinum neurotoxin B metalloprotease. The method allows for the synthesis of additional hydroxyethylene dipeptide isosteres such as 2 with functionalized P1 side chains. The isosteres prepared were coupled with a dipeptide to produce protected pseudotetrapeptide derivatives.