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Synthesis of a Chiral Aziridine Derivative as a Versatile Intermediate for HIV Protease Inhibitors

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journal contribution
posted on 29.06.2001, 00:00 by B. Moon Kim, Sung Jin Bae, Soon Mog So, Hyun Tae Yoo, Sun Ki Chang, Jung Hwan Lee, JaeSung Kang
Chiral aziridine derivative 1 was prepared from d-tartaric acid. This compound could be utilized as a common intermediate for the synthesis of hydroxyethylamine class HIV protease inhibitors such as saquinavir, amprenavir, or nelfinavir.