Synthesis of
Xanthones via Copper(II)-Catalyzed Dehydrogenative
Cyclization and Successive Aromatization in a One-Step Sequence

Jang, Yoon Hu; Yang, Yo-Sep; Son, Seung Hwan; Yoo, Hyung-Seok; Shin, Jeong-Won; Won, Hyuck-Jae; Kim, Soo Lim; Lim, Changjin; Kim, Nam-Jung

doi:10.1021/acs.orglett.2c03730.s001

ol2c03730_si_001.pdf (7.97 MB)

Synthesis of Xanthones via Copper(II)-Catalyzed Dehydrogenative Cyclization and Successive Aromatization in a One-Step Sequence

journal contribution

posted on 2022-12-13, 18:05 authored by Yoon Hu Jang, Yo-Sep Yang, Seung Hwan Son, Hyung-Seok Yoo, Jeong-Won Shin, Hyuck-Jae Won, Soo Lim Kim, Changjin Lim, Nam-Jung Kim

In this study, an unprecedented approach to the xanthone scaffold from cyclohexyl(2-hydroxyphenyl)methanone via dehydrogenative cyclization and a successive aromatization cascade is reported. This methodology affords a novel route to the privileged structure with a wide substrate scope (a total of 29 compounds, ≤96% yield) in a highly atom-economic manner.