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Synthesis of Unsymmetrical Diarylureas via Pd-Catalyzed C–N Cross-Coupling Reactions

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journal contribution
posted on 17.06.2011, 00:00 by Simon Breitler, Nathan J. Oldenhuis, Brett P. Fors, Stephen L. Buchwald
A facile synthesis of unsymmetrical N,N′-diarylureas is described. The utilization of the Pd-catalyzed arylation of ureas enables the synthesis of an array of diarylureas in good to excellent yields from benzylurea via a one-pot arylation–deprotection protocol, followed by a second arylation.