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Download fileSynthesis of Unsymmetrical 2,6-Diarylanilines by Palladium-Catalyzed C–H Bond Functionalization Methodology
journal contribution
posted on 07.05.2018, 11:48 authored by Se Hun Kwak, Nurbey Gulia, Olafs Daugulis3,5-Dimethylpyrazole was employed
as a monodentate directing group
for palladium-catalyzed ortho-sp2 C–H
arylation with aryl iodides. The reaction shows good functional group
tolerance and outstanding selectivity for mono-ortho-arylation. Ozonolysis of ortho-arylated arylpyrazoles
gave acylated biphenylamines that were further arylated to afford
unsymmetrically substituted 2,6-diarylacetanilides.